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Subsequent oral or parenteral administration, barbiturates easily cross the placental barrier and they are dispersed all through fetal tissues with greatest concentrations found in the placenta, fetal liver and Mind. Fetal blood levels technique maternal blood levels next parenteral administration.Nursing Mothers: Caution must be exercised when phe
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Nonteratogenic Effects. Reports of infants suffering from very long-time period barbiturate exposure in utero involved the acute withdrawal syndrome of seizures and hyperirritability from delivery into a delayed onset of around fourteen times (see DRUG ABUSE AND DEPENDENCE).Phenobarbital was introduced to marketplace in 1912 via the drug company Ba